Models of Ion and Substrate Cotransport and the Effect of the Membrane Potential
نویسنده
چکیده
The implications of a carrier model of ion and substrate cotransport are worked out. Each carrier is assumed to have one ion and one substrate binding site. The model includes features that have not been included in previously published models. These features are the effect of the membrane potential and of the assumption that all carrier forms, with or without bound substrate and with or without various bound ions, can cross the membrane. The model is of a two-state (gate-type) carrier with transition rate constants. In one state the carrier interacts with outer bulk phase; in the other state it interacts with the inner bulk phase. Equilibrium in the reactions between ion, substrate, and carrier is assumed at each surface.
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